3-Methoxypropylamine → (5-Bromo-2-nitrophenyl)(3-methoxypropyl)amine

Participants

Reaction Steps

A solution of 26.49 g of 2,4-dibromo-1-nitrobenzene [51686-78-3] and 70 ml of 3-methoxypropylamine is stirred at room temperature for 4 hours and subsequently left to stand at 3° C. for 2 days. The reaction mixture is concentrated by evaporation. The title compound is obtained as a yellow oil from the residue by means of flash chromatography (SiO2 60 F). Rf=0.4 (1:3 EtOAc-heptane). Rt=4.99 (gradient I).

Provenance & Evidence