3-Methoxypropyne → HCID 66889153, compound

HRID 2263532Notes

Reaction equation

HRID 2263532 reaction equation
FC(F)(F)S(O[C:7]1[C:11]2[CH:12]=[C:13]([Br:16])[CH:14]=[CH:15][C:10]=2[O:9][CH:8]=1)(=O)=O.[CH3:19][O:20][CH2:21][C:22]#[CH:23]>>[Br:16][C:13]1[CH:14]=[CH:15][C:10]2[O:9][CH:8]=[C:7]([C:23]#[C:22][CH2:21][O:20][CH3:19])[C:11]=2[CH:12]=1

Participants

3

Reactant 2

HCID 693933-MethoxypropyneHCID 11772326HCID 11772326, compound

Product 1

HCID 66889153HCID 66889153, compound

Procedure

Analogously to residue 9a, 9.31 g of 5-bromobenzofuran-3-yl trifluoromethanesulphonate [440083-74-9] and 3.52 ml of 3-methoxypropyne are reacted. The title compound is obtained as a yellowish oil. Rf=0.43 (1:10 EtOAc-heptane); Rt=5.14 (gradient I).

Sources & evidence

ORD record
ord-a1ebc0cc1351428b85e3806f86f04c8b
Source dataset
uspto-grants-2010_12
Patent number
US07851634B2

Reaction notes

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