Formic Acid → N-((4-bromopyridin-2-yl)methyl)formamide

20.00 g of C-(4-bromopyridin-2-yl)methylamine are taken up in 60 ml of formic acid and the solution is heated to reflux over 3 hours. The reaction solution is cooled to room temperature and concentrated by evaporation, and the residue is taken up in saturated aqueous sodium hydrogencarbonate solution (300 ml) and the aqueous solution extracted with dichloromethane (3×300 ml). The combined organic phases are washed with water (300 ml), dried over sodium sulphate and concentrated by evaporation. The title compound is identified on the basis of the Rf value from the residue by means of flash chromatography (SiO2 60 F).

1. temperaturethe solution is heated
2. temperatureto reflux over 3 hours
3. concentrationconcentrated by evaporation
4. extractionthe aqueous solution extracted with dichloromethane (3×300 ml)
5. washThe combined organic phases are washed with water (300 ml)
6. dry with materialdried over sodium sulphate
7. concentrationconcentrated by evaporation

ORD record

ord-bf1ecb4899cf41dfafd6b8ba40d4ceaa

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07851634B2