Succinic anhydride → HCID 131728588, compound

HRID 2263567Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:51]2[CH:56]=[CH:55][C:54]([O:57][CH3:58])=[CH:53][CH:52]=2)[O:10][CH:11]([C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[CH:12]2[CH2:16][CH:15]([OH:17])[CH2:14][N:13]2[C:18](=[O:44])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:43])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[CH:5][CH:4]=1.[C:59]1(=[O:65])[O:64][C:62](=[O:63])[CH2:61][CH2:60]1>>[CH3:58][O:57][C:54]1[CH:53]=[CH:52][C:51]([CH:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[O:10][CH:11]([C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[CH:12]2[N:13]([C:18](=[O:44])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:43])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:14][CH:15]([O:17][C:59](=[O:65])[CH2:60][CH2:61][C:62]([OH:64])=[O:63])[CH2:16]2)=[CH:56][CH:55]=1

Participants

Reactant 2

HCID 7922Succinic anhydride

HCID 131728584HCID 131728584, compound

Product 1

HCID 131728588HCID 131728588, compound

Procedure

Using the above described procedure, the amide 102e (2.4 g, 3 mmol) was treated with succinic anhydride and after work-up the amide was isolated as a foam (2.69 g, 99%) and this was used in the next step without further purification.

Sources & evidence

ORD record: ord-02297c3c14ae4c0097543fd9199285ed
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851615B2

Reaction notes

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