Succinic anhydride → HCID 131728590, compound

HRID 2263569Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:55]2[CH:60]=[CH:59][C:58]([O:61][CH3:62])=[CH:57][CH:56]=2)[O:10][CH:11]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[CH:12]2[CH2:16][CH:15]([OH:17])[CH2:14][N:13]2[C:18](=[O:48])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:47])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])=[CH:5][CH:4]=1.[C:63]1(=[O:69])[O:68][C:66](=[O:67])[CH2:65][CH2:64]1>>[CH3:62][O:61][C:58]1[CH:57]=[CH:56][C:55]([CH:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[O:10][CH:11]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[CH:12]2[N:13]([C:18](=[O:48])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:47])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])[CH2:14][CH:15]([O:17][C:63](=[O:69])[CH2:64][CH2:65][C:66]([OH:68])=[O:67])[CH2:16]2)=[CH:60][CH:59]=1

Participants

Reactant 2

HCID 7922Succinic anhydride

HCID 131728587HCID 131728587, compound

Product 1

HCID 131728590HCID 131728590, compound

Procedure

Using the above described procedure, the amide 102h (2.56 g, 3 mmol) was treated with succinic anhydride and after work-up the amide was isolated as a foam (2.8 g, 99%) and this was used in the next step without further purification.

Sources & evidence

ORD record: ord-bc4fe6b0c1da4a6ca171bd428e56ced1
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851615B2

Reaction notes

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