HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2263590Generated: November 1, 2026
Triphenylphosphine → 4-Bromo-2-(bromomethyl)-1-chlorobenzene
https://huagongshe.com/reaction/2263590
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | (5-Bromo-2-chlorophenyl)methanol | HCID 5074766 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Bromo-2-(bromomethyl)-1-chlorobenzene | HCID 11558280 | — |
Reaction Steps
4.0 g N-bromosuccinimide are slowly added to a solution of 5.0 g of 4-bromo-1-chloro-2-hydroxymethyl-benzene and 5.9 g triphenylphosphine in 50 ml of tetrahydrofuran chilled to 5° C. After 1 h stirring at ambient temperature the precipitate is filtered off and the solvent is eliminated in vacuo. The residue is purified through silica gel (cyclohexane/ethyl acetate 50:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07851602B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-c3299fb0732e4b598a6957e81330dfb3 |
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| Source note | uspto-grants-2010_12 |
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