p-Toluenesulfonic acid → HCID 726870, compound

Participants

Reaction Steps

Prepared according to general procedure using (E)-tert-butyl 2-(2-hydroxyphenylcarbonyl)-3-p-tolylprop-2-enoate (54 mg, 0.16 mmol), thiourea catalyst III (11 mg, 0.016 mmol) in 1.6 mL toluene for 36 h at −25° C. and p-toluenesulfonic acid (15 mg, 0.08 mmol) for 25 h. Purification via column chromatography with 10% EtOAc/hexanes afforded 32 mg (83%) of 10 as a white solid in 90% ee. Analytical data match those reported in the literature.6

Provenance & Evidence