反应详情

Prepared according to general procedure using (E)-tert-butyl 3-(2-chlorophenyl)-2-(2-hydroxyphenylcarbonyl)prop-2-enoate (36 mg, 0.10 mmol), thiourea catalyst III (7 mg, 0.010 mmol) in 1.0 mL toluene for 36 h at −25° C. and p-toluenesulfonic acid (10 mg, 0.05 mmol) for 50 h. Purification via column chromatography with 10% EtOAc/hexanes afforded 19 mg (67%) of 11 as a white solid in 88% ee. Analytical data match those reported in the literature.6

1. customPrepared
2. customfor 36 h
3. customat −25° C.
4. customPurification via column chromatography with 10% EtOAc/hexanes