反应详情

[2-(3,3-Dicyclohexyl-ureido)-thiazol-4-yl]acetic acid ethyl ester was prepared from dicyclohexylamine and (2-amino-4-thiazolyl)acetic acid ethyl ester as described in general procedure (A). To this compound was added 1.3 equivalents of N-bromosuccinimide suspended in acetic acid, and the mixture was stirred for 3 h at RT. The reaction mixture was concentrated in vacuo, redissolved in dichloromethane, washed with 10% sodium sulphate, water, aqueous sodium bicarbonate, brine and then dried over magnesium sulphate. Flash chromatography afforded the title compound.

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionredissolved in dichloromethane
3. washwashed with 10% sodium sulphate, water, aqueous sodium bicarbonate, brine
4. dry with materialdried over magnesium sulphate