Dicyclohexylamine → HCID 57883736, compound

HRID 2263716Notes

Reaction equation

HRID 2263716 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:14])=[N:9][C:8]=1[CH3:28])C.C1(NC2CCCCC2)CCCCC1.CN1C=C(N)SC1.C(OC(=O)CS)C>>[CH:22]1([N:15]([CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:29])=[O:3])=[C:8]([CH3:28])[N:9]=2)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 7582DicyclohexylamineHCID 86611178HCID 86611178, compoundHCID 86611179HCID 86611179, compound

Product 1

HCID 57883736HCID 57883736, compound

Procedure

[2-(3,3-Dicyclohexyl-ureido)-4-methyl-thiazol-5-ylsulfanyl]-acetic acid ethyl ester prepared as described in general procedure (A) using dicyclohexylamine and 3-methyl-5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-23412216b2b3446e8f3a53a2140feee4
Source dataset
uspto-grants-2010_12
Patent number
US07851636B2

Reaction notes

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