Methyl iodide → 1-(1-Butyryl-piperidin-4-yl)-1-cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-urea

HRID 2263752Notes

Reaction equation

[C:1]([N:6]1[CH2:11][CH2:10][CH:9]([N:12]([CH:24]2[CH2:29][CH2:28][CH:27](C)[CH2:26][CH2:25]2)[C:13]([NH:15][C:16]2[S:17][C:18]([S:21][C:22]#N)=[CH:19][N:20]=2)=[O:14])[CH2:8][CH2:7]1)(=[O:5])[CH2:2][CH2:3][CH3:4].SC[C@@H]([C@@H](CS)O)O.CI>>[C:1]([N:6]1[CH2:7][CH2:8][CH:9]([N:12]([CH:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[C:13]([NH:15][C:16]2[S:17][C:18]([S:21][CH3:22])=[CH:19][N:20]=2)=[O:14])[CH2:10][CH2:11]1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 439352Dithioerythritol

HCID 866111891-(1-Butyryl-piperidin-4-yl)-1-(4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea

Product 1

HCID 578836551-(1-Butyryl-piperidin-4-yl)-1-cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-urea

Procedure

Prepared as described in general procedure (H) and (I) using 1-(1-butyryl-piperidin-4-yl)-1-(4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and methyliodide.

Workup

customPrepared

Sources & evidence

ORD record: ord-f27f816694c54f9bae95f6c036cdf807
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851636B2

Reaction notes

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