1,1-Dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea → HCID 57883518, compound

HRID 2263786Notes

Reaction equation

HRID 2263786 reaction equation
[CH:1]1([N:7]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH:16]=O)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.C([O:32][C:33]([CH:35]1[O:40][CH2:39][CH2:38][NH:37][CH2:36]1)=[O:34])C1C=CC=CC=1>>[CH:18]1([N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8](=[O:9])[NH:10][C:11]2[S:12][C:13]([CH2:16][N:37]3[CH2:38][CH2:39][O:40][CH:35]([C:33]([OH:34])=[O:32])[CH2:36]3)=[CH:14][N:15]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 578834711,1-Dicyclohexyl-3-(5-formyl-thiazol-2-yl)-ureaHCID 66872108HCID 66872108, compound

Product 1

HCID 57883518HCID 57883518, compound

Procedure

Prepared 11 mg (58%) following the general procedures (P) and (F) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (70 mg. 0.21 mmol) and morpholine-2-carboxylic acid benzyl ester hydrochloride (77 mg, 0.30 mmol).

Workup

  1. customPrepared 11 mg (58%)

Sources & evidence

ORD record
ord-933090e0c6a54526b4abee1b0f1a7828
Source dataset
uspto-grants-2010_12
Patent number
US07851636B2

Reaction notes

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