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HRID 2263800作成日：2026年10月26日
1,1'-Carbonyldiimidazole → 4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/2263800
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 2-Amino-1,3-thiazole-5-carbaldehyde | HCID 2737798 | — |
| 反応物 | 4-(4-Methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 43652146 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester | HCID 57883803 | 357.1% |
反応手順
Prepared in a manner similar to general procedure (C) using 5-formyl-2-aminothiazole (1.88 g, 14.6 mmol), 4-(4-methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester (4.32 mg, 14.6 mmol), catalytic DMAP, CDI (2.60 g, 1.1 mmol) and THF with heating to 65° C. afforded 1.77 g (27%) of the desired product after purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07851636B2 |
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| 出典データセット | uspto-grants-2010_12 |
|---|
| ORD ID | ord-7777dbf6b2e34b27bee5a473aefefee2 |
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| 出典メモ | uspto-grants-2010_12 |
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