HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 226384Generated: October 26, 2026
tert-butyl (3R)-3-{[3-chloro-5-(hydroxymethyl)-2-pyridinyl]amino}-1-piperidinecarboxylate → tert-butyl (3R)-3-[(3-chloro-5-formyl-2-pyridinyl)amino]-1-piperidinecarboxylate
https://huagongshe.com/reaction/226384
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-butyl (3R)-3-{[3-chloro-5-(hydroxymethyl)-2-pyridinyl]amino}-1-piperidinecarboxylate | HCID 86603693 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | tert-butyl (3R)-3-[(3-chloro-5-formyl-2-pyridinyl)amino]-1-piperidinecarboxylate | HCID 86603692 | 91.3% |
Reaction Steps
A mixture of tert-butyl (3R)-3-{[3-chloro-5-(hydroxymethyl)-2-pyridinyl]amino}-1-piperidinecarboxylate (10.0 g) and MnO2 (25.4 g) in CHCl3 (200 ml) was stirred at 60° C. for 3.5 hours. After removal of the insoluble material, and the solvent was evaporated in vacuo to give tert-butyl (3R)-3-[(3-chloro-5-formyl-2-pyridinyl)amino]-1-piperidinecarboxylate (9.08 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07557127B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-85fcc967627b433c97b11083bf961a89 |
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| Source note | uspto-grants-2009_07 |
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