2-(Piperazin-1-yl)acetamide dihydrochloride → 2-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-(Piperazin-1-yl)acetamide dihydrochloride	HCID 17750375	—
Edukt	(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 58894207	—
Produkt	2-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamide	HCID 17754802	—

Reaktionsschritte

In a manner analogous to the method described in example 5, (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 4) was reacted with 2-piperazin-1-yl-acetamide dihydrochloride (Matrix Scientific) to give the title compound. HR-MS (ES, m/z) calculated for C36H44N5O3Cl2 [(M+H)+] 664.2816, observed 664.2810.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07851626B2
Quelldatensatz	uspto-grants-2010_12
ORD ID	ord-602a9a9061be4c958e7ff2dd19f4fb92
Quellennotiz	uspto-grants-2010_12