1-(2-Hydroxyethyl)piperazine → [(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Hydroxyethyl)piperazine	HCID 7677	—
Reactant	(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 58894207	—
Product	[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone	HCID 17754846	—

Reaction Steps

In a manner analogous to the method described in example 5, (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 4) was reacted with 2-piperazin-1-yl-ethanol (Chemical Dynamics) to give the title compound. HR-MS (ES, m/z) calculated for C36H45N4O3Cl2 [(M+H)+] 651.2863, observed 651.2863.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07851626B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-8ada8be4fa4548bd81ff27073b111e4c
Source note	uspto-grants-2010_12