Trimethylaluminum → 5-[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-1H-imidazol-2-yl]-2-tert-butyl-4-ethoxy-N,N-dimethylbenzenesulfonamide

Participants

Reaction Steps

In a manner analogous to the method described in example 2, meso-2,3-bis-(4-chlorophenyl)-2,3-butanediamine (example 1) was reacted with 4-tert-butyl-5-dimethylsulfamoyl-2-ethoxy-benzoic acid methyl ester (prepared in an analogous manner as described in example 43) in the presence of trimethylaluminum to give rac-5-[(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-2-yl]-2-tert-butyl-4-ethoxy-N,N-dimethyl-benzenesulfonamide.

Provenance & Evidence