HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 22639Erstellt: 26. Oktober 2026
Sodium Carbonate → 4'-[3-tert-Butoxycarbonyl-3-(3-cyanophenyl)-2-propylcarbazoylamino]-N-tert-butylbiphenyl-2-sulfonamide
https://huagongshe.com/reaction/22639
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)- | HCID 4997616 | — |
| Edukt | tert-Butyl 2-(3-cyanophenyl)-3-(4-iodophenylaminocarbonyl)-3-propylcarbazate | HCID 11191609 | — |
| Katalysator | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Lösungsmittel | 1,2-Dimethoxyethane | HCID 8071 | — |
| Produkt | 4'-[3-tert-Butoxycarbonyl-3-(3-cyanophenyl)-2-propylcarbazoylamino]-N-tert-butylbiphenyl-2-sulfonamide | HCID 11342464 | 75,6% |
Reaktionsschritte
1.5 g (2.883 mmol) of 405 and 1.112 g (4.324 mmol) of 2-(t-butylamino-sulfonyl)phenylboronic acid are dissolved in 100 ml of ethylene glycol dimethyl ether, treated with 63 mg (0.086 mmol) of PdCl2(dppf) and 20.0 ml of 2N sodium carbonate solution and then stirred at 110° C. under a nitrogen atomsphere for 3 h. After customary work-up, 1.32 g (75.6%) of 406 are thus obtained as crystals having a melting point of 173-174° C.; MS(FAB)=606.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06849626B2 |
|---|
| Quelldatensatz | uspto-grants-2005_02 |
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| ORD ID | ord-b43242805e624d7fadd674e498ef0b5e |
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| Quellennotiz | uspto-grants-2005_02 |
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