2-(Piperazin-1-yl)acetamide dihydrochloride → HCID 17754767, compound

HRID 2263973Notes

Reaction equation

HRID 2263973 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:36])[C:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)([CH3:13])[N:11]([C:21](Cl)=[O:22])[C:10]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][C:25]=3[O:32][CH:33]([CH3:35])[CH3:34])=[N:9]2)=[CH:4][CH:3]=1.Cl.Cl.[N:39]1([CH2:45][C:46]([NH2:48])=[O:47])[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@:8]2([CH3:36])[C@:12]([C:14]3[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=3)([CH3:13])[N:11]([C:21]([N:42]3[CH2:43][CH2:44][N:39]([CH2:45][C:46]([NH2:48])=[O:47])[CH2:40][CH2:41]3)=[O:22])[C:10]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][C:25]=3[O:32][CH:33]([CH3:34])[CH3:35])=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 177503752-(Piperazin-1-yl)acetamide dihydrochlorideHCID 72455751HCID 72455751, compound

Product 1

HCID 17754767HCID 17754767, compound

Procedure

In a manner analogous to the method described in example 5, rac-(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with 2-piperazin-1-yl-acetamide dihydrochloride (Matrix Scientific) to give the title compound. HR-MS (ES, m/z) calculated for C34H40N5O4Cl2 [(M+H)+] 652.2452, observed 652.2451.

Sources & evidence

ORD record
ord-291b879dd33944b5bf8f795fe113a72a
Source dataset
uspto-grants-2010_12
Patent number
US07851626B2

Reaction notes

Loading…