HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → HCID 53256448, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | (R)-tert-Butyl 1-(3-methoxybenzyl)pyrrolidin-3-ylcarbamate | HCID 53256447 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 53256448 | HCID 53256448 | — |
Reaction Steps
To a solution of tert-butyl [(3R)-1-(3-methoxybenzyl)-3-pyrrolidinyl]carbamate (739 mg) in ethyl acetate (3.7 mL) was added 4N HCl-ethyl acetate (6.0 mL), which was stirred at room temperature for 1.5 hours. The mixture was concentrated to give (3R)-1-(3-methoxybenzyl)-3-pyrrolidinamine dihydrochloride (702 mg) as a off-white amorphous.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557127B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-165286584b2b43e6bb0a164c59cd4d82 |
| Source note | uspto-grants-2009_07 |