Bis(2-Methoxyethyl)amine → rac-(4S,5R)-2-(4-tert-Butyl-2-isopropoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carboxylic acid bis-(2-methoxy-ethyl)-amide

Participants

Role	Name	HCID	Charge
Reactant	Bis(2-Methoxyethyl)amine	HCID 2383	—
Reactant	rac-(4S,5R)-2-(4-tert-Butyl-2-isopropoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 72455766	—
Product	rac-(4S,5R)-2-(4-tert-Butyl-2-isopropoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carboxylic acid bis-(2-methoxy-ethyl)-amide	HCID 68686628	—

Reaction Steps

In a manner analogous to the method described in example 5, rac-(4S*,5R*)-2-(4-tert-butyl-2-isopropoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with bis-(2-methoxyethyl)-amine (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C37H49N4O5SCl2 [(M+H)+] 668.3017, observed 668.3010.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07851626B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-210fdb5d62f14ef4a55e107866b78e80
Source note	uspto-grants-2010_12