rac-(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole → HCID 68681803, compound

HRID 2264030Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:14][CH2:15][CH3:16])=[C:9]([CH:13]=1)[C:10](Cl)=O)([CH3:4])([CH3:3])[CH3:2].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2([CH3:50])[C:28]([C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)([CH3:29])[NH:27]C(C3C=CC(C(C)(C)C)=CC=3OCC)=[N:25]2)=[CH:20][CH:19]=1>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:14][CH2:15][CH3:16])=[C:9]([C:10]2[NH:25][C:24]([C:21]3[CH:20]=[CH:19][C:18]([Cl:17])=[CH:23][CH:22]=3)([CH3:50])[C:28]([C:30]3[CH:31]=[CH:32][C:33]([Cl:36])=[CH:34][CH:35]=3)([CH3:29])[N:27]=2)[CH:13]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 53628801rac-(4S*,5R*)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole

HCID 82631794HCID 82631794, compound

Product 1

HCID 68681803HCID 68681803, compound

Procedure

rac-(4S,5R*)-2-(5-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole was prepared from 5-tert-butyl-2-ethoxy-benzoyl chloride (prepared from 5-tert-butyl-2-hydroxy-benzoic acid) and meso-2,3-bis-(4-chlorophenyl)-2,3-butanediamine (example 1) in an analogous manner as described in example 2 (method 1).

Sources & evidence

ORD record: ord-7e639e9f3b444f7bb4801f482f3c6c89
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851626B2

Reaction notes

Loading…