2-Ethoxybenzoic acid → HCID 68683899, compound

HRID 2264032Notes

Reaction equation

HRID 2264032 reaction equation
[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:5]=1[C:6](Cl)=O)[CH3:2].C(OC1C=CC=CC=1C(O)=O)C.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2([CH3:62])[C:40]([C:42]3[CH:47]=[CH:46][C:45]([Cl:48])=[CH:44][CH:43]=3)([CH3:41])[NH:39]C(C3C=CC(C(C)(C)C)=CC=3OCC)=[N:37]2)=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2([CH3:62])[C:40]([C:42]3[CH:43]=[CH:44][C:45]([Cl:48])=[CH:46][CH:47]=3)([CH3:41])[NH:39][C:6]([C:5]3[CH:9]=[C:10]([S:13]([CH3:16])(=[O:15])=[O:14])[CH:11]=[CH:12][C:4]=3[O:3][CH2:1][CH3:2])=[N:37]2)=[CH:32][CH:31]=1

Participants

4

Reactant 3

HCID 672522-Ethoxybenzoic acidHCID 53628801rac-(4S*,5R*)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazoleHCID 86612885HCID 86612885, compound

Product 1

HCID 68683899HCID 68683899, compound

Procedure

rac-(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-5-methanesulfonyl-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole was prepared from 2-ethoxy-5-methanesulfonyl-benzoyl chloride (prepared from 2-ethoxy-benzoic acid in an analogous as described in example 59) and meso-2,3-bis-(4-chlorophenyl)-2,3-butanediamine (example 1) in an analogous manner as described in example 2 (method 1).

Sources & evidence

ORD record
ord-a953616d75e8488db4ee6a28dc384d33
Source dataset
uspto-grants-2010_12
Patent number
US07851626B2

Reaction notes

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