HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → HCID 68683466, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | 4-Bromo-2-hydroxybenzoic acid | HCID 268737 | — |
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | rac-(4S*,5R*)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole | HCID 53628801 | — |
| Reactant | HCID 86612889 | HCID 86612889 | — |
| Product | HCID 68683466 | HCID 68683466 | — |
Reaction Steps
rac-(4S*,5R*)-4,5-Bis-(4-chloro-phenyl)-2-(4-cyclopropyl-2-ethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole was prepared from 4-cyclopropyl-2-ethoxy-benzoyl chloride (prepared from 4-bromo-2-hydroxy-benzoic acid by alkylation with iodoethane, Suzuki coupling with cyclopropyl boronic acid, then saponification and conversion to the chloride) and meso-2,3-bis-(4-chlorophenyl)-2,3-butanediamine (example 1) in an analogous manner as described in example 2 (method 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851626B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-e92efc4d7cbd4c3ea25452644ea96cd8 |
| Source note | uspto-grants-2010_12 |