HCID 21196419, compound → HCID 68684760, compound

HRID 2264044Notes

Reaction equation

C(C1C=CC(C(Cl)=O)=C(OC)C=1)(C)(C)C.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2([CH3:49])[C:27]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)([CH3:28])[NH:26][C:25]([C:36]3[CH:41]=[CH:40][C:39]([C:42]([CH3:45])([CH3:44])[CH3:43])=[CH:38][C:37]=3[O:46][CH2:47]C)=[N:24]2)=[CH:19][CH:18]=1>>[C:42]([C:39]1[CH:40]=[CH:41][C:36]([C:25]2[NH:26][C:27]([C:29]3[CH:30]=[CH:31][C:32]([Cl:35])=[CH:33][CH:34]=3)([CH3:28])[C:23]([C:20]3[CH:21]=[CH:22][C:17]([Cl:16])=[CH:18][CH:19]=3)([CH3:49])[N:24]=2)=[C:37]([O:46][CH3:47])[CH:38]=1)([CH3:43])([CH3:44])[CH3:45]

Participants

Reactant 2

HCID 21196419HCID 21196419, compound

HCID 53628801rac-(4S*,5R*)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole

Product 1

HCID 68684760HCID 68684760, compound

Procedure

rac-(4S*,5R*)-2-(4-tert-butyl-2-methoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole was prepared from 4-tert-butyl-2-methoxy-benzoyl chloride (prepared from 4-tert-butyl-2-hydroxy-benzoic acid) and meso-2,3-bis-(4-chlorophenyl)-2,3-butanediamine (example 1) in an analogous manner as described in example 2 (method 1).

Sources & evidence

ORD record: ord-cb21aa3610e54bf8b68cd913f371c453
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851626B2

Reaction notes

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