n,n-Dimethylpiperazine-1-carboxamide → HCID 58894226, compound

HRID 2264064Notes

Reaction equation

HRID 2264064 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:31](Cl)=[O:32])[CH:13]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=3)[C:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:34][CH2:35][CH3:36])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:37][N:38]([CH3:47])[C:39]([N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)=[O:40]>>[CH3:37][N:38]([CH3:47])[C:39]([N:41]1[CH2:42][CH2:43][N:44]([C:31]([N:12]2[C@H:13]([C:24]3[CH:25]=[CH:26][C:27]([Cl:30])=[CH:28][CH:29]=3)[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=[C:11]2[C:8]2[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:6][C:7]=2[O:34][CH2:35][CH3:36])=[O:32])[CH2:45][CH2:46]1)=[O:40]

Participants

3

Reactant 2

HCID 712909n,n-Dimethylpiperazine-1-carboxamideHCID 72455720rac-(4S*,5R*)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4-methyl-4,5-dihydro-imidazole-1-carbonyl chloride

Product 1

HCID 58894226HCID 58894226, compound

Procedure

In a manner analogous to the method described in example 5, rac-(4S*,5R*)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4-methyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with piperazine-1-carboxylic acid dimethylamide (Aldrich) to give the title compound. LC-MS: 664.3 [(M+H)+]

Sources & evidence

ORD record
ord-0183c7a639644c58a721732a77ff3801
Source dataset
uspto-grants-2010_12
Patent number
US07851626B2

Reaction notes

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