1-((Pyrrolidine-1-carbonyl)methyl)piperazine → HCID 58894276, compound

HRID 2264066Notes

Reaction equation

HRID 2264066 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:35])[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20](Cl)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:34])[CH3:33])=[N:9]2)=[CH:4][CH:3]=1.[N:36]1([CH2:42][C:43]([N:45]2[CH2:49][CH2:48][CH2:47][CH2:46]2)=[O:44])[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@:8]2([CH3:35])[C@@H:12]([C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[N:11]([C:20]([N:39]3[CH2:38][CH2:37][N:36]([CH2:42][C:43]([N:45]4[CH2:46][CH2:47][CH2:48][CH2:49]4)=[O:44])[CH2:41][CH2:40]3)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:33])[CH3:34])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1006141-((Pyrrolidine-1-carbonyl)methyl)piperazineHCID 86612897HCID 86612897, compound

Product 1

HCID 58894276HCID 58894276, compound

Procedure

In a manner analogous to the method described in example 5, rac-(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4-methyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with 2-piperazin-1-yl-1-pyrrolidin-1-yl-ethanone (Aldrich) to give the title compound. LC-MS: 692.3 [(M+H)+]

Sources & evidence

ORD record
ord-4b0f57bec288417b99a9d49c748c2a4c
Source dataset
uspto-grants-2010_12
Patent number
US07851626B2

Reaction notes

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