2-(Piperazin-1-yl)acetamide dihydrochloride → HCID 58894279, compound

HRID 2264072Notes

Reaction equation

HRID 2264072 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:35])[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20](Cl)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:34])[CH3:33])=[N:9]2)=[CH:4][CH:3]=1.Cl.Cl.[N:38]1([CH2:44][C:45]([NH2:47])=[O:46])[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@:8]2([CH3:35])[C@@H:12]([C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[N:11]([C:20]([N:41]3[CH2:42][CH2:43][N:38]([CH2:44][C:45]([NH2:47])=[O:46])[CH2:39][CH2:40]3)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:33])[CH3:34])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 177503752-(Piperazin-1-yl)acetamide dihydrochlorideHCID 86612897HCID 86612897, compound

Product 1

HCID 58894279HCID 58894279, compound

Procedure

In a manner analogous to the method described in example 5, rac-(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4-methyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with 2-piperazin-1-yl-acetamide dihydrochloride (Matrix Scientific) to give the title compound. LC-MS: 638.2 [(M+H)+]

Sources & evidence

ORD record
ord-eedb44e495d749728d5e03bbe56d6aad
Source dataset
uspto-grants-2010_12
Patent number
US07851626B2

Reaction notes

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