n,n-Dimethylpiperazine-1-carboxamide → HCID 58894259, compound

HRID 2264073Notes

Reaction equation

HRID 2264073 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:35])[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20](Cl)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:34])[CH3:33])=[N:9]2)=[CH:4][CH:3]=1.[CH3:36][N:37]([CH3:46])[C:38]([N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)=[O:39]>>[CH3:36][N:37]([CH3:46])[C:38]([N:40]1[CH2:41][CH2:42][N:43]([C:20]([N:11]2[C@H:12]([C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[C@@:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)([CH3:35])[N:9]=[C:10]2[C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=2[O:31][CH:32]([CH3:33])[CH3:34])=[O:21])[CH2:44][CH2:45]1)=[O:39]

Participants

3

Reactant 2

HCID 712909n,n-Dimethylpiperazine-1-carboxamideHCID 86612897HCID 86612897, compound

Product 1

HCID 58894259HCID 58894259, compound

Procedure

In a manner analogous to the method described in example 5, rac-(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4-methyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with piperazine-1-carboxylic acid dimethylamide (Aldrich) to give the title compound. LC-MS: 652.2 [(M+H)+]

Sources & evidence

ORD record
ord-83e555a334ed4fb4ae7a4b334b77ac12
Source dataset
uspto-grants-2010_12
Patent number
US07851626B2

Reaction notes

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