HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Dota | HCID 121841 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane | HCID 107830 | — |
Reaction Steps
8.0 equivalents of DOTA mono acid was dissolved in NMP and treated with 8.0 equivalents of HBTU and 16.0 equivalents of DIEA. This solution was stirred for 15 min at RT and then transferred to the amine on the resin and the coupling was continued for 24 h at RT. The resin was then drained, washed and then the peptide was cleaved and purified.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07850947B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-0da1712c0f1b43bea9f9891c304ba261 |
| Source note | uspto-grants-2010_12 |