Salicyl Alcohol → Diethyl 2-hydroxybenzylphosphonate

Participants

Reaction Steps

At first, 38.4 g of 2-hydroxybenzylalcohol from TOKYO KASEI KOGYO Co., Ltd. and 80 ml of o-xylene were put in a reaction vessel having a stirrer, a thermometer and a dropping funnel. Under a nitrogen gas flow, 62.8 g of triethyl phosphite was slowly dropped therein at 80° C., and the reaction was further performed for 1 hour at the same temperature. Next, the produced ethanol, the solvent (o-xylene) and unreacted triethyl phosphite were removed from the reaction by reduced-pressure distillation. Thus, 66 g of 2-diethylhydroxybenzylphosphonate having a boiling point of 120.0° C./1.5 mm Hg was prepared. In this reaction, the yield was 90%.

Provenance & Evidence