HCID 57432117, compound → HCID 16122905, compound

Participants

Reaction Steps

(S)-(+)-4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide and (R)-(−)-4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide. Resolution into the pure enantiomers was performed by preparative HPLC using isocratic elution on ChiralPak AD at 1 mL/min, eluting with 100% ethanol. Under these conditions, the (R)-(−)-isomer elutes second after the (S)-(+)-isomer. (S)-(+)-4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide: [α]D25° C.=+10° (c=1, MeOH), (R)-(−)-4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide: [α]D25° C.=−10° (c=1, MeOH)

Provenance & Evidence