反应详情

To an cooled solution (−78° C. internal temp) of 0.5 g of methyl 2-methoxy-6-methylpyrimidine-4-carboxylate in 15 mL of toluene and 15 mL of dichloromethane was added 6 mL of 1 M diisobutyl aluminum hydride in toluene. After stirring 10 min the reaction was quenched with 5 mL of water, allowed to warm to room temperature and dried with 5 g of MgSO4. Concentration of the filtrate under reduced pressure gave the product as an resin and was used without further purification: MS (m+1)=153.1 and 171.1 (hydrate).

1. customwas quenched with 5 mL of water
2. dry with materialdried with 5 g of MgSO4
3. customConcentration of the filtrate under reduced pressure gave the product as an resin
4. customwas used without further purification