反应详情

温度

80 °C

To a solution of 3″-fluoro-3,2′:3′,4″-terpyridine-5′,6′-diamine (Intermediate 1, 0.2 g, 0.71 mmol) in pyridine (2 mL), 0.071 mL (0.78 mmol) of cyclopropanoylcarbonyl chloride were added. The mixture was heated at 80° C. for 4 h and the solvent was evaporated. The crude mixture was extracted between ethyl acetate and water, the organic layer was dried (MgSO4) and evaporated. The residue was purified by silica gel flash chromatography (90:10 dichloromethane/methanol) to give the title compound (0.202 g, 82% of yield).

1. customthe solvent was evaporated
2. extractionThe crude mixture was extracted between ethyl acetate and water
3. dry with materialthe organic layer was dried (MgSO4)
4. customevaporated
5. customThe residue was purified by silica gel flash chromatography (90:10 dichloromethane/methanol)