4-Fluorobenzoyl chloride → HCID 178505539, compound

Participants

Reaction Conditions

Reaction Steps

3″-Fluoro-3,2′:3′,4″-terpyridine-5′,6′-diamine (Intermediate 1,158 mg, 0.56 mmol), 4-fluorobenzoyl chloride (73.0 μL, 0.62 mmol) and pyridine (ca. 4 mL) were placed in a sealed tube. The solution was initially heated at 140° C. for 48 h and afterwards, at 160° C. for another 48 h. Then, the reaction mixture was cooled to room temperature, the pyridine was removed in vacuo, and the crude oil was purified by flash column chromatography (CH2Cl2/EtOH, 95:5) affording the title compound as a white solid (141 mg, 65%).

Provenance & Evidence