反应详情

温度

40 °C

To a solution of 3″-fluoro-3,2′:3′,4″-terpyridine-5′,6′-diamine (Intermediate 1, 0.2 g, 0.71 mmol) in pyridine (2 mL), 0.071 mL (0.78 mmol) of 3-fluoro-4-methylbenzoyl chloride were added. The mixture was heated at 40° C. for 4 h and the solvent was evaporated. The crude mixture was extracted between ethyl acetate and water, the organic layer was dried (MgSO4) and evaporated to give the title compound (0.295 g, 88% of yield) which was used in the next step without further purification.

1. customthe solvent was evaporated
2. extractionThe crude mixture was extracted between ethyl acetate and water
3. dry with materialthe organic layer was dried (MgSO4)
4. customevaporated