反应详情

A solution of N-(6′-amino-3″-fluoro-3,2′:3′,4″-terpyridin-5′-yl)-3-fluoro-4-methylbenzamide (0.12 g, 0.288 mmol) in acetic acid (2 mL) was heated in a sealed tube at 118° C. for 16 h. The solvent was evaporated and 4% sodium bicarbonate aqueous solution was added and extracted with ethyl acetate. The organic layer was dried and evaporated. The residue was purified by silica gel flash chromatography (95:5 dichloromethane/methanol) to give the title compound (0.03 g, 26% of yield).

1. customThe solvent was evaporated
2. addition4% sodium bicarbonate aqueous solution was added
3. extractionextracted with ethyl acetate
4. customThe organic layer was dried
5. customevaporated
6. customThe residue was purified by silica gel flash chromatography (95:5 dichloromethane/methanol)