HCID 59595983, compound → HCID 178481236, compound

HRID 2264215Notes

Reaction equation

HRID 2264215 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[C:5]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][C:15]=2[F:20])=[CH:4][C:3]=1[NH:21][C:22]([C:24]1[N:28]([CH3:29])[CH:27]=[N:26][CH:25]=1)=O>C(O)(=O)C>[F:20][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][C:14]=1[C:5]1[CH:4]=[C:3]2[N:21]=[C:22]([C:24]3[N:28]([CH3:29])[CH:27]=[N:26][CH:25]=3)[NH:1][C:2]2=[N:7][C:6]=1[C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 1

HCID 59595983HCID 59595983, compound

Product 1

HCID 178481236HCID 178481236, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of N-(6′-amino-3″-fluoro-3,2′:3′,4″-terpyridin-5′-yl)-1-methyl-1H-imidazole-5-carboxamide (0.040 g, 0.103 mmol) in acetic acid (1 mL) was heated in a sealed tube at 118° C. for 16 h. The solvent was evaporated and 4% sodium bicarbonate aqueous solution was added and extracted with ethyl acetate. The organic layer was dried and evaporated to give the title compound (0.022 g, 58% of yield).

Workup

  1. customThe solvent was evaporated
  2. addition4% sodium bicarbonate aqueous solution was added
  3. extractionextracted with ethyl acetate
  4. customThe organic layer was dried
  5. customevaporated

Sources & evidence

ORD record
ord-53d1e33f31204e95a59d6e30849a4db7
Source dataset
uspto-grants-2010_12
Patent number
US07855202B2

Reaction notes

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