HCID 178508301, compound → HCID 178505987, compound

HRID 2264222Notes

Reaction equation

HRID 2264222 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[C:5]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][C:15]=2[F:20])=[CH:4][C:3]=1[NH:21][C:22]([C:24]1[N:28]=[CH:27][NH:26][N:25]=1)=O>C(O)(=O)C>[F:20][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][C:14]=1[C:5]1[CH:4]=[C:3]2[N:21]=[C:22]([C:24]3[NH:28][CH:27]=[N:26][N:25]=3)[NH:1][C:2]2=[N:7][C:6]=1[C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 1

HCID 178508301HCID 178508301, compound

Product 1

HCID 178505987HCID 178505987, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of N-(6′-amino-3″-fluoro-3,2′:3′,4″-terpyridin-5′-yl)-1H-1,2,4-triazole-3-carboxamide (0.070 g, 0.19 mmol) in acetic acid (2.5 mL) was heated in a sealed tube at 120° C. for 18 h. The solvent was evaporated and the residue was suspended in ethyl acetate and 4% sodium bicarbonate aqueous solution. The solid formed was filtered and dried in vacuo to give the title compound (0.039 g, 59% of yield).

Workup

  1. customThe solvent was evaporated
  2. customThe solid formed
  3. filtrationwas filtered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-70b5646c6f6b4f46be82faa6e0ba5ee5
Source dataset
uspto-grants-2010_12
Patent number
US07855202B2

Reaction notes

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