HCID 59596028, compound → HCID 178521601, compound

Participants

Reaction Steps

Using the procedure of example 1, trans-4-amino-cyclohexanol (200 mg) was reacted with compound 1f (100 mg) to provide compound 18 (18 mg, 22%). 1H NMR (400 MHz, CD3OD) δ 8.95 (d, J=8.0 Hz, 1H), 8.28 (d, J=4.8 Hz, 1H), 8.20 (s, 1H), 8.13 (d, J=5.6 Hz, 1H), 7.26 (dd, J=8.0 Hz, 4.8. Hz, 1H), 7.02 (d, J=5.2 Hz, 1H), 3.91 (m, 1H), 3.65 (m, 1H), 2.17 (m, 2H), 2.05 (m, 2H), 1.45 (m, 4H). MS (ESI) m/z: 310 (M+H)+.

Provenance & Evidence