2-Aminophenol → HCID 44416137, compound

HRID 2264253Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C1(S([N:18]2[C:22]3=[N:23][CH:24]=[CH:25][CH:26]=[C:21]3[C:20]([C:27]3[CH:32]=[CH:31][N:30]=[C:29](Cl)[N:28]=3)=[CH:19]2)(=O)=O)C=CC=CC=1>>[OH:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:29]1[N:28]=[C:27]([C:20]2[C:21]3[C:22](=[N:23][CH:24]=[CH:25][CH:26]=3)[NH:18][CH:19]=2)[CH:32]=[CH:31][N:30]=1

Participants

Reactant 2

HCID 58012-Aminophenol

HCID 59596028HCID 59596028, compound

Product 1

HCID 44416137HCID 44416137, compoundYield 43%

Procedure

Using the procedure of example 1, 2-aminophenol (88 mg) was reacted with compound 1f (100 mg) to provide compound 30 (35 mg, 43%). 1H NMR (400 MHz, CD3OD) δ 8.83 (d, J=8.0 Hz, 1H), 8.28 (m, 2H), 8.25 (s, 1H), 7.91 (d, J=7.6 Hz, 1H), 7.22 (m, 2H), 6.97 (m, 1H), 6.91 (m, 2H). MS (ESI) m/z: 304 (M+H)+.

Sources & evidence

ORD record: ord-7a4cdec49b684902a262cbaf0c9ce9c5
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07855205B2

Reaction notes

Loading…