1,4-Diaminocyclohexane → HCID 178511658, compound

Participants

Reaction Steps

Using the procedure of example 1, trans-1,4-cyclohexyldiamine (277 mg) was reacted with compound 1f (300 mg) to provide compound 42 (86 mg, 34%). 1H NMR (400 MHz, CD3OD) δ 8.90 (d, J=8.0 Hz, 1H), 8.25 (d, J=5.6 Hz, 1H), 8.17 (s, 1H), 8.12 (d, J=8.0 Hz, 1H), 7.22 (m, 1H), 6.95 (d, J=5.6 Hz, 1H), 3.85 (m, 1H), 2.78 (m, 1H), 2.18 (m, 2H), 2.20 (m, 2H), 1.40 (m, 4H). MS (ESI) m/z: 309 (M+H)+.

Provenance & Evidence