4-Amino-1-methylpiperidine → HCID 56676921, compound

HRID 2264267Notes

Reaction equation

HRID 2264267 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([NH2:8])[CH2:4][CH2:3]1.C1(S([N:18]2[C:22]3=[N:23][CH:24]=[CH:25][CH:26]=[C:21]3[C:20]([C:27]3[CH:32]=[CH:31][N:30]=[C:29](Cl)[N:28]=3)=[CH:19]2)(=O)=O)C=CC=CC=1>>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:29]2[N:28]=[C:27]([C:20]3[C:21]4[C:22](=[N:23][CH:24]=[CH:25][CH:26]=4)[NH:18][CH:19]=3)[CH:32]=[CH:31][N:30]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 59596028HCID 59596028, compound

Product 1

HCID 56676921HCID 56676921, compoundYield 41%

Procedure

Using the procedure of example 1, 1-methylpiperidin-4-ylamine (30 mg) was reacted with compound 1f (30 mg) to provide compound 61 (10.2 mg, 41%). 1H NMR (300 MHz, CD3OD) δ 8.92 (d, 1 H), 8.23 (d, 1 H), 8.15 (s, 1 H), 8.10 (d, 1 H), 7.25 (m, 1 H), 7.00 (d, 1 H), 3.96 (m, 1 H), 3.05 (m, 2 H), 2.45 (m, 2 H), 2.15 (m, 2 H), 1.95 (s, 3 H), 1.75 (m, 2H). MS (ESI) m/z: 309 (M+H)+.

Sources & evidence

ORD record
ord-3a716e8828ec4ad89b41f908481d25a4
Source dataset
uspto-grants-2010_12
Patent number
US07855205B2

Reaction notes

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