4-Piperidinamine → HCID 56673427, compound

HRID 2264268Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([NH2:7])[CH2:3][CH2:2]1.C1(S([N:17]2[C:21]3=[N:22][CH:23]=[CH:24][CH:25]=[C:20]3[C:19]([C:26]3[CH:31]=[CH:30][N:29]=[C:28](Cl)[N:27]=3)=[CH:18]2)(=O)=O)C=CC=CC=1>>[NH:17]1[C:21]2=[N:22][CH:23]=[CH:24][CH:25]=[C:20]2[C:19]([C:26]2[CH:31]=[CH:30][N:29]=[C:28]([N:1]3[CH2:6][CH2:5][CH:4]([NH2:7])[CH2:3][CH2:2]3)[N:27]=2)=[CH:18]1

Participants

Reactant 2

HCID 4243614-Piperidinamine

HCID 59596028HCID 59596028, compound

Product 1

HCID 56673427HCID 56673427, compoundYield 72%

Procedure

Using the procedure of example 1, piperidin-4-ylamine (540 mg) was reacted with compound 1f (500 mg) to provide compound 62 (285 mg, 72%). 1H NMR (400MHz, DMSO) δ 8.70 (d, 1 H), 8.40 (s, 1 H), 8.25 (m, 1 H), 8.20 (d, 1 H), 7.20 (m, 1 H), 7.05 (d, 1 H), 4.60 (d, 2 H), 3.05 (m, 2 H), 2.85 (m, 1 H), 1.85 (m, 2 H), 1.25 (m, 2 H). MS (ESI) m/z: 295 (M+H)+.

Sources & evidence

ORD record: ord-3bdb49bf5758402ab17a707d9bd380e8
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07855205B2

Reaction notes

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