Pyridine → HCID 58692198, compound

Participants

Reaction Steps

To a flask was added compound 62 (10.2 mg), acetic anhydride (0.5 mg), pyridine (0.1 mL) and THF (1 mL) at 0° C. The mixture was warmed to rt slowly and stirred for 1 hr, then poured into water and extracted with EtOAc. The organic layer was separated, dried with MgSO4, then concentrated to provide 10.9 mg (94%) of the desired product as a white solid. 1H NMR (400 MHz, DMSO) δ 12.30 (s, 1 H), 8.70 (d, 1 H), 8.40 (s, 1 H), 8.25 (m, 1 H), 8.20 (d, 1 H), 7.80 (d, 1 H), 7.25 (m, 1 H), 7.10 (d, 1 H), 4.60 (d, 2 H), 3.90 (m, 1 H), 3.15 (m, 2 H), 1.85 (m, 2 H), 1:80 (s, 3 H), 1.40 (m, 2 H). MS (ESI) m/z: 337 (M+H)+.

Provenance & Evidence