1-(4-Aminopiperidin-1-yl)ethan-1-one → HCID 58692219, compound

Participants

Reaction Steps

Using the procedure of example 1, 1-(4-aminopiperidin-1-yl)ethanone (350 mg) was reacted with compound 1f (300 mg) to provide compound 64 (33 mg, 12%). 1H NMR (300 MHz, CDCl3) δ 11.45 (s, 1 H), 8.75 (d, 1 H), 8.40 (d, 1 H), 8.20 (d, 1 H), 8.12 (s, 1 H), 8.00 (s, 1 H), 7.20 (m, 1H), 6.90 (d, 1 H), 5.40 (m, 1 H) (rotamer), 4.55 (m, 1 H), 4.20-3.70 (m, 2 H), 3.40-2.70 (m, 2 H), 2.20 (m, 2 H), 2.15 (s, 3 H), 1.50 (m, 2H). MS (ESI) m/z: 337 (M+H)+.

Provenance & Evidence