Acetic Anhydride → HCID 44415978, compound

HRID 2264274Notes

Reaction equation

HRID 2264274 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]=[C:12]([C:14]3[C:22]4[C:17](=[N:18][CH:19]=[CH:20][CH:21]=4)[NH:16][CH:15]=3)[CH:11]=[CH:10][N:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[CH:1]1([NH:7][C:8]2[N:13]=[C:12]([C:14]3[C:22]4[C:17](=[N:18][CH:19]=[CH:20][CH:21]=4)[N:16]([C:23](=[O:25])[CH3:24])[CH:15]=3)[CH:11]=[CH:10][N:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 44415977HCID 44415977, compound

Product 1

HCID 44415978HCID 44415978, compoundYield 86%

Procedure

Using the procedure of example 66, compound 13 (24 mg) and acetic anhydride (7.7 μL) were used to provide compound 68 (24 mg, 86%). 1H NMR (300 MHz, CDCl3) δ 8.85 (d, 1 H), 8.52 (d, 1 H), 8.40 (d, 1 H), 8.28 (d, 1 H), 7.35 (dd, 1 H), 6.90 (d, 1 H), 5.15 (m, 1 H), 3.92 (m, 1 H), 2.15 (m, 2 H), 1.85 (m, 2 H), 1.70 (m, 2 H), 1.50 (m, 2 H), 1.30 (m, 2 H). MS (ESI) m/z: 336 (M+H)+.

Sources & evidence

ORD record
ord-b0399b71a39e4209828326f94d2f41cc
Source dataset
uspto-grants-2010_12
Patent number
US07855205B2

Reaction notes

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