HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → Methyl 2-chloro-6-(dimethylamino)-5-fluoronicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Methyl 2,6-dichloro-5-fluoronicotinate | HCID 2775354 | — |
| Product | Methyl 2-chloro-6-(dimethylamino)-5-fluoronicotinate | HCID 23112242 | — |
Reaction Steps
Methyl 2,6-dichloro-5-fluoronicotinate was treated with dimethylamine in a sealed tube to obtain methyl 2-chloro-6-(dimethylamino)-5-fluoronicotinate, which was then reacted under a hydrogen atmosphere in the presence of palladium/carbon to obtain methyl 6-(dimethylamino)-5-fluoronicotinate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855198B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-292c54c6c3c042789f3711f1365d9494 |
| Source note | uspto-grants-2010_12 |