Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2264338Generated: October 30, 2026

Sodium Hydroxide → HCID 23112218, compound

https://huagongshe.com/reaction/2264338

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantHCID 23112217HCID 23112217—
SolventEthanolHCID 702—
ProductHCID 23112218HCID 23112218—

Reaction Steps

5-Chloro-6-[(2,4-dimethoxybenzyl)amino]nicotinate was treated with sodium hydroxide in ethanol to obtain 5-chloro-6-[(2,4-dimethoxybenzyl)amino]nicotinic acid. To the compound were added toluene, diphenylphosphoryl azide (DPPA), tert-butyl alcohol, and triethylamine, and the whole was stirred under reflux with heating. The resulting compound was treated with trifluoroacetic acid to obtain 3-chloropyridin-2,5-diamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07855198B2
Source datasetuspto-grants-2010_12
ORD IDord-adf6c121d60947f0be04247fa784e9e1
Source noteuspto-grants-2010_12