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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2264340Generated: October 26, 2026

Dimethylamine → N,N-dimethyl-5-nitro-3-(trifluoromethyl)pyridin-2-amine

https://huagongshe.com/reaction/2264340

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylamineHCID 674—
ReactantThionyl ChlorideHCID 24386—
Reactant2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridineHCID 2775095—
Reactant2-Chloro-5-nitro-3-(trifluoromethyl)pyridineHCID 3849140—
ProductN,N-dimethyl-5-nitro-3-(trifluoromethyl)pyridin-2-amineHCID 2727273—

Reaction Steps

5-Nitro-3-(trifluoromethyl)pyridin-2(1H)-one was treated with thionyl chloride and then the resulting 2-chloro-5-nitro-3-(trifluoromethyl)pyridine was treated with dimethylamine to obtain N,N-dimethyl-5-nitro-3-(trifluoromethyl)pyridin-2-amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07855198B2
Source datasetuspto-grants-2010_12
ORD IDord-7cb0851813ff4549af4c32eae90ec652
Source noteuspto-grants-2010_12